The Science of Bio-Regeneration
Our formulation is powered by BeautiFerm® Healerine, a fermented active derived from Reishi mushroom (Ganoderma lucidum) — traditionally known as the “Mushroom of Immortality” for its long history in restorative practices.
Research into its fermentation process shows Healerine supports skin regeneration and barrier recovery, jumpstarting the skin’s natural renewal process
Skin Renewal, Studied at Every Stage
As we age, the skin’s natural ability to renew itself and repair its barrier slows down. Research on BeautiFerm® Healerine — the same concentration used in RENEW — shows it activates biological mechanisms involved in skin renewal:
Boosts Natural Regeneration — In vivo studies at 1% concentration showed 26.71% more regenerated tissue volume within 24 hours of skin disruption, compared to placebo.
Depth & Volume Reduction — 3D topography imaging recorded a 62% reduction in wound depth and a 21% reduction in total wound volume after 24 hours, at 1% concentration.
Essential Cellular Support — In vitro research shows Healerine stimulates the proliferation of keratinocytes — the cells responsible for maintaining skin homeostasis, a strong barrier, and healthy cell renewal. Separate lab testing recorded a 45% increase in the speed of epidermal re-epithelialization at 0.1% concentration.
Barrier Recovery — In a 28-day in vivo study, twice-daily application reduced skin barrier recovery time by up to 26% — 5 days faster than the untreated control, following a chemical insult.
Calming Support — In vitro research shows Healerine lightly inhibits NF-κB transcription in skin cells, a pathway linked to inflammatory response
Advanced Barrier Support
A resilient skin barrier is the skin’s first line of defense against environmental stress. BeautiFerm® Healerine acts as a natural solution to support barrier recovery:
Accelerated Recovery — In a 28-day in vivo study, skin barrier function recovered up to 3 days faster on average with twice-daily application, compared to placebo — with the best responders recovering up to 6 days faster.
Visible Calming — Skin treated with Healerine showed visibly reduced redness and no crusting, compared to placebo, in imaging taken 24 hours after treatment.
The Fermentation Advantage
Unlike standard extracts, our ingredient is a postbiotic created through a strictly controlled biotechnology process:
Enhanced Bioavailability — Fermentation research shows this process improves how skin can access and use the Reishi mushroom’s naturally occurring compounds.
Microbiome Friendly — This aqueous fermented active supports a balanced and healthy skin microbiome.
Broad-Spectrum Bioactives — Fermentation unlocks a rich profile of Reishi mushroom compounds, including triterpenoids, beta-glucans, and immune-supportive proteins, each contributing to the skin barrier and skin’s natural defenses.
Cosmetic Use Disclaimer
N°6602 products are cosmetic formulations for external use only. Information provided on this website is for educational and informational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
Performance data and ingredient properties reflect ingredient-level research, based on laboratory or cosmetic testing and published scientific literature. Results may vary between individuals.
Safety Note: Always perform a patch test before use and discontinue if irritation occurs.
Cosmetic Testing & Data Interpretation
These results reflect ingredient-level performance under controlled research conditions and are not intended to represent clinical medical outcomes for N°6602’s finished products. Individual results may vary.
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N°6602 is a South African natural skincare brand creating botanical-driven formulations for face and body, rooted in indigenous plant intelligence and modern bioactive science.
© South Africa - N°6602
All Rights Reserved
N°6602 is a South African natural skincare brand creating botanical-driven formulations for face and body, rooted in indigenous plant intelligence and modern bioactive science.
© South Africa - N°6602
All Rights Reserved